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Spiny Mice Regenerating Damaged Kidneys Without Fibrosis

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Published By:
Peeyush Ghalot
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Published On:
23-12-2021

Spiny mice have had a reputation for healing severe skin wounds without leaving a scar. Researchers have now revealed that they can also heal badly injured internal organs that otherwise result in organ failure in other mice. Loss of crucial organ function owing to increasing tissue fibrosis has a substantial global health cost. Patients with end-stage kidney disease or other degenerative fibrotic illnesses of the heart, lungs, liver, or reproductive systems now have few therapy choices. To discover out, the researchers subjected spiny mice to circumstances that have been shown to induce substantial kidney damage in other mice. The study found that while spiny mice suffer from the same level of tissue damage as humans, they can recover fully: they regenerated a healthy kidney with no evidence of fibrosis. Other mice given the same treatment died of organ failure, as predicted. The rapid and complete recovery of renal function in spiny mice over two weeks was rather astonishing.

(Picture: - Science Direct)

To figure out how the spiny mice accomplish it, the researchers looked at all of the genes they express. Their findings show that the spiny mouse genome is ready to begin a quick, scarless regeneration response in surviving kidney cells at the time of damage. Macrophages did not present for approximately a week in these animals, unlike other mice. Scientists have opened a new door in discovering potential therapeutics for chronic kidney illness, which might also apply to other organs that suffer from increased tissue fibrosis.

Reference: - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055364/