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First occurrence of infection caused by diabetic treatment in India.

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Peeyush Ghalot
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(Image Courtesy: - The Economic Times)

Following the lead of the United States and Canada, India has confirmed the occurrence of an uncommon but dangerous infection of the genitals and the region around the genitals in Type-2 diabetes patients taking sodium-glucose cotransporter-2 (SGLT2) inhibitors. Necrotizing fasciitis of the perineum, often known as Fournier's gangrene, is a dangerous, uncommon illness. All State Drug Controllers have been asked by the Central Drugs Standard Control Organization to direct the manufacturers of SGLT2 inhibitor class drugs named Canagliflozin, Dapagliflozin, and Empagliflozin under their jurisdiction to include warnings in the package insert and promotional literature. After metformin, sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase IV (DPP-IV) inhibitors are recommended as preferred add-on oral anti-diabetic drugs (OADs) in type-2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and chronic kidney disease (CKD). They are often much more expensive than other OADs. Diabetes is a long-term metabolic disorder characterized by high blood glucose (or blood sugar) levels, which can harm the heart, blood vessels, eyes, kidneys, and nerves. The most prevalent is type-2 diabetes, which affects adults and arises when the body becomes insulin resistant or produces insufficient insulin. Type-2 diabetes has become much more common in countries of all income levels during the last three decades.

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